产品名称：Bifikafusp alfa
产品别称：L19-IL2
靶点：FN extracellular domain B [Homo sapiens]
抗体亚型：scFv - heavy - kappa
来源：Sp2/0-Ag14 mouse hybridoma cells
体内模型：在原位胰腺癌小鼠模型中，Bifikafusp alfa能够抑制肿瘤生长和转移、具有**的长期肿瘤抑制性[1]。
| Animal Model | NMRI nude mice with MiaPaca-A2 xenografts |
| Dosage | 1.43 and 4.29 MIU/kg |
| Result | Reduced tumor volume to 21.4% (1.43 MIU/kg) and 2.7% (4.29 MIU/kg) compared with control mice. |
参考文献：1.Wagner K, Schulz P, Scholz A, Wiedenmann B, Menrad A. The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. Clin Cancer Res. 2008;14(15):4951-4960. doi:10.1158/1078-0432.CCR-08-0157
仅供科研使用
